Abstract
In this study effect of gamma irradiation sterilization and storage conditions on thermal properties of phase sensitive granisetron in situ forming implant (ISFI) was investigated. ISFI was prepared by mixing Poly(DL-lactide-co-glycolide) (PLGA) with dimethylsulfoxide (DMSO):propylene carbonate (PC) (1:1) solvent combination then granisetron HCl was added and homogenized. Following application of gamma irradiation, ISFI was stored at 25oC for 4 months. Differential Scanning Calorimeter (DSC) and Thermogravimetric Analysis-Differential Thermal Analysis (TGA-DTA) analysis were carried out on fresh, irradiated and aged forms of granisetron ISFI. According to DSC and TGA-DTA thermograms and mass loss results application of gamma irradiation and storage of irradiated ISFI at 25oC for 4 months have not significant effect on thermal stability of ISFI.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
