Year-end Sale % OFF 
Abstract
Nanosecond Pulsed Electric Fields (nsPEF) have the potential to treat a variety of cancer types including melanoma, pancreatic and lung squamous cancers. Recent studies show that nsPEF-based cancer therapy may be improved further with the assistance of moderate heating of the target. A feedback-looped heating system, utilizing a 980-nm fiber optic laser, was integrated into nsPEF electrodes for tumor ablation. The laser beam profile was determined to be Gaussian using a knife-edge technique. Thermal properties of the biological target were evaluated based on the treatment area, penetration depth and thermal distribution due to laser irradiation with or without nsPEF. Synergistic effects between nsPEF and the moderately elevated temperature at the target was observed, resulting in enhanced overall survival tumor regression up to 50% in the treatment of lung squamous cell cancer in mice.
Highlights
The use of Nanosecond Pulsed Electric Fields in biological studies is known for providing a non-thermal treatment alternative due to its unique biological effects such as apoptosis in cells and tumors[1,2,3], activation of signaling pathways used in cell death[4,5] and transferring specific genes into cells through cell membrane permeation[6]
When applying the electric field using a needle-array electrode, the field strength is strongest near the needles, and decreases substantially as the field moves away, resulting in a highly non-uniform electric field distribution and uneven treatment results
Synergistic effects of local temperature enhancements on cellular responses to intense Nanosecond Pulsed Electric Fields (nsPEF), in additional to the electrical effect, were suggested using a molecular dynamics modeling[12]. This is important since these localized thermal contributions to bio-processes could be beneficial but the globally averaged temperature effects might still seem negligible[12]
Summary
The use of Nanosecond Pulsed Electric Fields (nsPEF) in biological studies is known for providing a non-thermal treatment alternative due to its unique biological effects such as apoptosis in cells and tumors[1,2,3], activation of signaling pathways used in cell death[4,5] and transferring specific genes into cells through cell membrane permeation[6]. After the tissue sample became mostly transparent to the laser irradiation, e.g. after 120 seconds heating, the distribution of the temperature, recorded by the thermal camera, revealed a Gaussian profile, matching the profile of the laser beam determined by the knife edge technique.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
