Abstract

It is known that FAD is an important cofactor for Nox isoform, as an electron carrier from NADPH to Fe(III) of the heme group then to molecular oxygen reducing it up to О2 [1, 6]. On the other hand, the thermostable Nox is isolated from thermostable microorganisms [5]. However, the role of FAD as a factor in changing the conformation and thermostability of Nox isoform has not yet been determined. The aim of the present work was to determine the corresponding conditions under which the thermostability and production of superoxide radicals are also observed in the absence of NADPH.

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