Abstract
Monoclonal anti-D antibodies induce lysis of rhesus-positive erythrocytes in the antibody-dependent cytolysis test with blood mononuclear cells, the activity of the best antibodies being 10–15 times higher than of polyclonal IgG. The activities of anti-D antibodies in the cytolysis test with monocytes and lymphocytes varied: only one monoclonal antibody was highly active in both tests, whereas polyclonal IgG caused no lysis of erythrocytes in the cytolysis test with monocytes but was active in the same test with lymphocytes. Monoclonal antibodies intravenously administered to rhesus-negative recipients after transfusion of rhesus-positive erythrocytes stimulated their clearance, but its rate was slower than with polyclonal antibodies. Erythrocytes sensitizedin vitro with monoclonal antibodies were completely removed from circulation within 3 h. It is not clear the results of which of the studied tests correlate with the capacity of anti-D immunoglobulins to block rhesus sensitization.
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