There is no correlation between the functional polymorphism −460C>T of vascular endothelial growth factor (VEGF) gene promoter and uncomplicated recurrent urinary tract infection among young women

Abstract

Abstract Introduction The −460C>T polymorphism in vascular endothelial growth factor (VEGF) gene promoter (rs833061) has robust association with various diseases including renal parenchymal scarring following urinary tract infection (UTI). However, the association of this polymorphism with uncomplicated recurrent UTI (RUTI) is still unclear. Aim The objective of this study was to assess the correlation between VEGF −460C>T polymorphism and uncomplicated RUTI among young women. Material and methods Polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) with BstU1 restriction enzyme – and DNA sequencing were used to determine the VEGF −460C>T polymorphism among 34 young adult women with uncomplicated RUTI and 34 healthy controls. Differences in genotype and allele frequencies between case and control groups were analyzed with χ2 test or Fisher's exact test. Results and discussion This study found that there was no significant difference in genotype frequencies between cases (CC 23.5%; CT 26.5%; TT 0%) and controls (CC 85.3%; CT 14.7%; AA 0%). Dominant model analysis found that there was no significant difference between uncomplicated RUTI and normal groups (P = 0.368). Similarly, allele analysis also found that there was no association between VEGF −460C>T polymorphism and uncomplicated RUTI (P = 0.398). Conclusions This study found that there was no correlation between VEGF −460C>T polymorphism and uncomplicated RUTI among young women.