There is no association of serum vitamin B levels with all-cause and cardiovascular mortality in hemodialysis patients.

Abstract

The impact of vitamin B metabolic disorders on hemodialysis (HD) patients' survival is unknown. This study is to investigate the association of serum vitamin B1, B3, B5, and B6 with all-cause and cardiovascular (CV) mortality in HD patients. Patients' baseline serum vitamin B1, B3, B5, and B6 levels were collected, and they were followed up for the occurrence of all-cause and CV death. Kaplan-Meier analysis and Cox proportional hazards model were used to examine the association of vitamin B with mortality. Seventy-six HD patients were included. The median follow-up time was 99 months. Kaplan-Meier analysis showed that baseline vitamin B5 < 69.0nmol/L and vitamin B6 < 8.1ng/ml were associated with a higher risk of CV mortality, but these associations were nullified after adjustment. Serum vitamins B1, B3, B5, and B6 were not associated with all-cause or CV mortality in HD patients. ChiCTR2200057078 (Chinese Clinical Trial Registry, https://www.chictr.org.cn/).