Abstract
Bone metastases affect a large number of oncological patients and can determine complications that can impact the quality of life of our patients and further translate into lessen treatment results and overall survival. Treatment with bisphosphonates (BP) has proven its efficacy in preventing the development of the complications related to bone metastases. BP are well tolerated in general but severe adverse events can occur, like osteonecrosis of the jaw (ONJ). Besides ONJ there are other dental and maxillofacial complications determined by BP, complications that by elementary preventive measures can be avoided.
Highlights
ORIENTATION ARTICLESTherapy with bone-modifying agents in cancer patients: efficacy versus adverse events in dental medicine
Bone metastases commonly affect patients with prostate, breast, kidney and lung cancer and patients with multiple myeloma and can determine skeletal complications known as skeletal related events (SRE) that impair the quality of life and survival of oncological patients
BP are recommended in patients with breast cancer and bone metastases, in patients with castration resistant prostate cancer and bone metastases, in patients with lung cancer, kidney cancer and other solid tumors with bone metastases and in patients with multiple myeloma [7]
Summary
Therapy with bone-modifying agents in cancer patients: efficacy versus adverse events in dental medicine. 3“Pius Brinzeu“ Timis County Emergency Clinical Hospital, Timisoara, Romania 4Oral Rehabilitation Department, “Iuliu Hatieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania 5Orthodontics Department, “G.E. Palade“ University of Medicine and Pharmacy Science and Technology, Tg. Mures, Romania 6Medical Oncology Department, “Iuliu Hatieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania 7“Prof. Dr Ion Chiricuta“ Oncology Institute, Cluj-Napoca, Romania Romania 6Medical Oncology Department, “Iuliu Hatieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania 7“Prof. Dr Ion Chiricuta“ Oncology Institute, Cluj-Napoca, Romania
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