Abstract
Cisplatin-based chemotherapy has become an accepted standard in the adjuvant treatment of Non–Small-cell lung cancer (NSCLC). We present a case of acute myelogenous leukemia with an 11q23/ MLL rearrangement diagnosed 1 year after the completion of 4 cycles of cisplatin and vinorelbine for resected NSCLC. To our knowledge, this is the first case of therapy-related acute myelogenous leukemia (t-AML) associated with this chemotherapy combination. The literature on t-AML with the 11q23/ MLL rearrangement is reviewed.
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