Abstract
The prevalence of kidney stone disease is increasing worldwide with significant health and economic burden. Newer research is finding that stones are associated with several serious morbidities. Yet, few randomized clinical trials or high quality observational studies have assessed whether clinical interventions decrease the recurrence of kidney stones. Therefore, in this review we analyze the available evidence on medical expulsive therapy for ureteral stones; describe the evidence about non-pharmacological stone therapy including dietary modifications and citrus juice-based therapy; and discuss the efficacy of thiazide diuretics for the treatment of hypercalciuria in recurrent nephrolithiasis.
Highlights
The occurrence of urolithiasis is high and increasing worldwide
In this review we analyze the available evidence on medical expulsive therapy for ureteral stones; describe the evidence about non-pharmacological stone therapy including dietary modifications and citrus juice-based therapy; and discuss the efficacy of thiazide diuretics for the treatment of hypercalciuria in recurrent nephrolithiasis
In the Spontaneous Urinary Stone Passage Enabled by Drugs (SUSPEND) trial, conducted in National Health Service hospitals in the United Kingdom, 1,136 patients harboring a single ureteral stone < 10 mm were randomized to a 4-week trial of tamsulosin, nifedipine, or placebo
Summary
The occurrence of urolithiasis is high and increasing worldwide. The lifetime risk of symptomatic kidney stones is approximately 13% in men and 7% in women.[1]. A large, well powered, placebo-controlled, multicenter, randomized trial was just published.[11] In the Spontaneous Urinary Stone Passage Enabled by Drugs (SUSPEND) trial, conducted in National Health Service hospitals in the United Kingdom, 1,136 patients harboring a single ureteral stone < 10 mm (located at any site in the ureter) were randomized to a 4-week trial of tamsulosin, nifedipine, or placebo. Furyk et al.[12] assessed the efficacy and safety of tamsulosin compared with placebo as MET in patients with distal ureteric stones less than or equal to 10 mm in diameter It was a multicenter, randomized, double-blind, placebo controlled trial conducted in 5 emergency departments (EDs) in a single state in Australia.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
