Abstract
Information about a favorable prognosis for a patient, recommendations for activities, and optimal pharmacotherapy are a mainstay in the effective treatment of acute nonspecific low back pain (NLBP). Standard pharmacotherapy for acute NLBP includes nonsteroidal anti-inflammatory drugs (NSAIDs). However, the longer their administration and larger doses, the higher the risk of side effects are. NSAIDs are contraindicated in some cases. In this connection, it has become necessary to search for new opportunities for the pharmacotherapy of acute NLBP. The results of experimental studies have demonstrated the analgesic and anti-inflammatory effects of high-dose B vitamins. Clinical trials have confirmed the efficacy of vitamin B complex (thiamine, pyridoxine, and cyanocobalamin) in the treatment of acute NLBP. The paper considers the practical significance of concomitant administration of B vitamins and NSAIDs in NLBP and notes the efficacy of milgamma used both alone and in combination with NSAIDs in the treatment of acute NLBP.
Highlights
optimal pharmacotherapy are a mainstay in the effective treatment of acute nonspecific low back pain
nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated in some cases
necessary to search for new opportunities for the pharmacotherapy
Summary
Information about a favorable prognosis for a patient, recommendations for activities, and optimal pharmacotherapy are a mainstay in the effective treatment of acute nonspecific low back pain (NLBP). Парацетамол признан малоэффективным у пациентов с острой ПНБ [19, 20], при этом риск гепатоксического действия у парацетамола выше, чем у любых других НПВП [21]. Сегодня накоплен определенный клинический опыт применения комбинированной терапии НПВП с витаминами группы В у пациентов с острой ПНБ.
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