Abstract
The accurate evaluation of the therapeutic effects of advanced laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) remains challenging. In this study, we determined the value of quantitative parameters derived from dual-energy computed tomography (DECT) for predicting the therapeutic effects of advanced LHSCC and to provide valuable evidence for early judgement of the tumour’s response to therapy in clinical practice. We prospectively analysed 41 patients with pathologically confirmed LHSCC. All patients received a DECT scan before therapy. Nineteen of 41 patients showed complete remission (CR), and 22 showed non-complete remission (NCR). The mean of the slope of spectral Hounsfield unit curve (λHU), standardized iodine concentration and effective atomic number in the CR group were significantly lower than the NCR group (P < 0.05). There were no significant differences for T stage, treatment modality and standardized water concentration between two groups (P > 0.05). The best predictor of CR effect was λHU. The 2-year cumulative recurrence rate of patients with higher λHU values was significantly higher than that of patients with lower λHU values (P < 0.05), while the 2-year survival rate of those patients was not significantly different (P > 0.05). DECT could easily identify CR patients and potentially help to choose the appropriate treatment regimen for advanced LHSCC.
Highlights
The accurate evaluation of the therapeutic effects of advanced laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) remains challenging
Patients presenting with technically resectable disease were offered non-surgical therapy in an attempt to preserve speech and/or swallowing function
Some studies suggest that chemotherapy plays a limited role in shrinking tumour volume and increasing long-term survival rate[20,21]
Summary
The accurate evaluation of the therapeutic effects of advanced laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) remains challenging. Non-surgical treatments, including CRC, IC + RT and RT combined with EGFRI, have been the available options for preserving organ function in laryngeal and hypopharyngeal cancer patients[10,11,12]. Patients, salvage surgery after radical radiotherapy would increase the risk of operative complications If those RT non-sensitive patients could be identified and have salvage surgery performed, the adverse effects of RT could be avoided. The purpose of this study was to prospectively compare the performance of quantitative parameters derived from dual-energy CT in the early prediction of therapeutic responses of advanced LHSCC patients
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