Abstract
More than fifty trials have carried out on the treatment of infantile spasms. There is still a lack of consensus about the treatment of first choice for infantile spasms. Up-to date information comparing hormonal therapy (ACTH and oral steroids) and vigabatrin show that hormonal therapy is more effective at day 14. Prednisolone is as effective as corticotrophin when used in maximal doses. This is in discrepancy with one recent theory, according to which the action of ACTH via steroids is likely to be of minor importance. Hormonal therapy might accelerate physiological events during critical stages of brain development.
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