Abstract
The basic problem in cancer treatment remains the identification of cells responsible for maintaining the whole population of cells in a tumor. For decades it has been considered that all transformed cells within a tumor have carcinogenic potential with unlimited proliferation capacity and metastases formation. At present, the concept of cancer stem cell was introduced indicating that tumor evolves from a small population of long-live and slow proliferating cells. These cells have the capacity to initiate the tumor formation in immunodeficient animals. Among their properties, resistance to standard oncology treatments leads to treatment failure and cancer recurrence. The management and eradication of different types cancer is completely depended on removal of this cell population. Current review presents basic information about cancer stem cell, particularly, the initiation of tumor, the peculiar properties of cancer stem cell, the role of cancer stem cell in metastasis formation and discusses therapeutic strategies targeted cancer stem cell.
Highlights
The basic problem in cancer treatment remains the identification of cells responsible for maintaining the whole population of cells in a tumor
For decades it has been considered that all transformed cells within a tumor have carcinogenic potential with unlimited proliferation capacity and metastases formation
The concept of cancer stem cell was introduced indicating that tumor evolves from a small population of long-live and slow proliferating cells
Summary
The basic problem in cancer treatment remains the identification of cells responsible for maintaining the whole population of cells in a tumor. Устойчивость самых разных опухолей к терапии в значительной мере определяется тем, что СКО сохраняют присущую нормальным СК экспрессию АВС-транспортеров. Повышение уровня АВС-транспортеров в СКО способствует быстрому выведению из клетки различных опасных для нее веществ, в том числе и противоопухолевых препаратов, необходимых для успешной терапии.
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