Abstract
Proteins that recognize the components and products of microorganisms have an important role in innate immunity. Here, I focus on recent advances in our understanding of the function of several such protein families. In particular, I consider how members of the TLR (Toll-like receptor), NOD (nucleotide-binding oligomerization domain)-protein and MyD88 (myeloid differentiation primary-response protein 88) families are providing emerging opportunities for the development of new therapeutics that modify innate immune responses in ways which benefit the host.
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