Abstract
Resveratrol, a natural phytoalexin, exhibits a remarkable range of biological activities, such as anticancer, cardioprotective, neuroprotective and antioxidant properties. However, the therapeutic application of resveratrol was encumbered for its low bioavailability. Therefore, many researchers focused on designing and synthesizing the derivatives of resveratrol to enhance the bioavailability and the pharmacological activity of resveratrol. During the past decades, a large number of natural and synthetic resveratrol derivatives were extensively studied, and the methoxylated, hydroxylated and halogenated derivatives of resveratrol received particular more attention for their beneficial bioactivity. So, in this review, we will summarize the chemical structure and the therapeutic versatility of resveratrol derivatives, and thus provide the related structure activity relationship reference for their practical applications.
Highlights
Resveratrol (3,5,40 -trihydroxystilbene) is a natural phytoalexin produced by numerous plants in response to ultraviolet radiation, injury, fungal or bacterial infection
The chemical structure of resveratrol is composed of two aromatic rings allied by a methylene bridge, and presents in both trans- and cis-isomeric forms naturally (Figure 1), the majority of the recorded medical advantages are attributed to trans-resveratrol but not its cis-form, so the structure activity relationship is the key point to determine the biological activities of resveratrol [5,6]
The last few decades, natural and synthetic novel therapeutic resveratrol derivatives receivedDuring much more of attention fromvarious pharmacologists and to resveratrol derivatives were studied, and the methoxylated, and natural halogenated enhance the therapeutic versatility of resveratrol
Summary
Resveratrol (3,5,40 -trihydroxystilbene) is a natural phytoalexin produced by numerous plants in response to ultraviolet radiation, injury, fungal or bacterial infection. Studies revealed thateffects the parent structure resveratrol is an essential component and is vital for itshave specific therapeutic [15]. OccurringSoand compounds show derivatives have received much more of attention from pharmacologists and to enhance different bioactivity but are related to their chemical structure. The last few decades, natural and synthetic novel therapeutic resveratrol derivatives receivedDuring much more of attention fromvarious pharmacologists and to resveratrol derivatives were studied, and the methoxylated, and natural halogenated enhance the therapeutic versatility of resveratrol. During the last fewhydroxylated decades, various and derivatives of resveratrol were received the special attention due to their diverse therapeutic synthetic resveratrol derivatives were studied, and the methoxylated, hydroxylated and halogenated potential. This review aims to highlight the role of the resveratrol derivatives such as methoxylated, derivatives of resveratrol were received the special attention due to their diverse therapeutic potential. Halogenated derivatives, and focus on their therapeutic versatility and their action mechanism
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