Therapeutic value of endoscopical therapy for small gastric stromal tumor

Abstract

Objective To investigate the safety and effectiveness of endoscopical therapy for small grastric stromal tumor(d<2 cm). Methods Clinical records of 80 patients dignosed as having small grastric stromal tumor by pathology and immunohistochemistry were retrospectively analyzed. Endoscopic or laparoscopic or open surgery was performed, so patients were divided into endoscopic treatment group (n=37) and surgical treatment group (n=43) accordingly. Perioperative period data, effectiveness and follow-up data were analysed. Results Thirty-five cases(94.6%) of endoscopic treatment group were successfully treated by endoscopic surgery. Intraoperative perforation occurred in 8 cases, among which 2 cases transferred for conventional operations.Pneumoperitoneum occurred in 2 cases (better after symptomatic treatment), while no serious infection or perioperative death occurred. There were no significant differences in the complete resection rate[91.89% (34/37) VS 100.0%(43/43), P=0.095), the incidence of postoperative complications[5.71%(2/35)VS 2.33%(1/43), P=0.855)or the improvement of postoperative symptoms[93.10% (27/29)VS 85.71% (30/35), P=0.589], while statistically significant differences were found in operation time[(37.41±13.45)min VS(84.56±38.37)min, P=0.000], intraoperative blood loss[(5.65±5.88)ml VS(31.48 ±39.57)ml, P=0.000], postoperative feeding time[(2.47±0.61)d VS(3.26 ±1.27)d, P=0.001], postoperative hospital stay[(5.76 ±2.28)d VS(7.64±2.99)d, P=0.022], and medical expenses[(18 554.4±9 736.45)yuan VS(31 138.11±1 206.24)yuan, P=0.000]. Conclusion Endoscopic resection is safe and effective for small grastric stromal tumor with minimal invasion, simple procedure, faster recovery and less economic burden for the patients. Key words: Endoscopes; Therapies, investigational; Stomach neoplasms