Abstract
The use of antibiotic-loaded cement spacers is an established method in the management of periprosthetic hip and knee joint infections. Despite inconsistencies among published studies, data shows that infection control rates exceed 90% with two-stage exchange arthroplasty. The present work reviews the current literature about antibiotic-loaded cement spacers and concentrates on the indications for spacer implantation, spacer production details, antibiotic impregnation, pharmacokinetic properties, clinical success, mechanical complications, and systemic safety.
Highlights
Over the past four decades, antibiotic-impregnated acrylic bone cement has been established as a valuable tool in the prophylaxis and treatment of orthopaedic infections
Low-dose antibiotic-impregnated bone cement is defined as ≤ 1 g antibiotic(s)/40 g polymethylmethacrylate (PMMA)
Anagnostakos et al determined the elution of gentamicin and vancomycin from beads and spacers in the drainage fluid using a two-stage protocol in the treatment of infected hip arthroplasties http://www.jbji.net
Summary
Over the past four decades, antibiotic-impregnated acrylic bone cement has been established as a valuable tool in the prophylaxis and treatment of orthopaedic infections. During the past two decades, antibiotic-loaded hip and knee spacers have become a popular method of managing such infections with reported success rates of > 90% [2,3].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
