Abstract
Aim: To assess the value of targeting the various molecules that regulate the epigenome in the management of cancer. Method: Peer-reviewed articles were examined in PubMed, Google Scholar, and ResearchGate search tools using keywords given in the manuscript. Main points: Three major epigenomic modifications, namely DNA methylation, histone methylation, and histone acetylation, attracted the most research interest and led to a few globally approved drugs for the treatment of various malignancies. The DNA methylation profiles of cancer have been successfully employed in many aspects of the management of this disease. Conclusion: Epigenomic profiling of cancer specimens has already been successfully employed in the management of cancer in a handful of specialized clinics, and this application could be extended further following more in-depth investigations in this field.
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