Abstract
N-propargylglycine prevents 4-hydroxyproline catabolism in mouse liver and kidney.N-propargylglycine is a novel suicide inhibitor of PRODH2 and induces mitochondrial degradation of PRODH2.PRODH2 is selectively expressed in liver and kidney and contributes to primary hyperoxaluria (PH).Preclinical evaluation of N-propargylglycine efficacy as a new PH therapeutic is warranted.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
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