Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information.

Yu Zong Chen,Ying Hong Li,Chu Qin,Zhe Chen,Jin Zhou,Feng Zhu,Chun Yan Yu,Hong Yang,Lin Tao,Feng Xu

doi:10.1093/nar/gkv1230

Abstract

Extensive drug discovery efforts have yielded many approved and candidate drugs targeting various targets in different biological pathways. Several freely accessible databases provide the drug, target and drug-targeted pathway information for facilitating drug discovery efforts, but there is an insufficient coverage of the clinical trial drugs and the drug-targeted pathways. Here, we describe an update of the Therapeutic Target Database (TTD) previously featured in NAR. The updated contents include: (i) significantly increased coverage of the clinical trial targets and drugs (1.6 and 2.3 times of the previous release, respectively), (ii) cross-links of most TTD target and drug entries to the corresponding pathway entries of KEGG, MetaCyc/BioCyc, NetPath, PANTHER pathway, Pathway Interaction Database (PID), PathWhiz, Reactome and WikiPathways, (iii) the convenient access of the multiple targets and drugs cross-linked to each of these pathway entries and (iv) the recently emerged approved and investigative drugs. This update makes TTD a more useful resource to complement other databases for facilitating the drug discovery efforts. TTD is accessible at http://bidd.nus.edu.sg/group/ttd/ttd.asp.

Highlights

The modern drug development efforts [1,2,3] have led to the discovery and clinical testing of thousands of targeted agents, and the approval of a considerable number of drugs. These agents produce their therapeutic effects by modulating various targets in different biological and disease regulatory pathways
Target and drug-targeted pathway information is freely available in the established drug [10], efficacy target [11], pharmacology [12], bioactive compound [13], binding [14] and pathway [15] databases, there is an inadequate coverage of the number and the detailed information of the clinical trial drugs in these databases
We evaluated some of the clinical trial drugs in the earlier (2004–2010) versions of several commercial databases against the publicly accessible literature, company reports and company announcements to select those drugs reported in the public sources

Summary

Introduction

The modern drug development efforts [1,2,3] have led to the discovery and clinical testing of thousands of targeted agents, and the approval of a considerable number of drugs. The second is the cross-linking of most of the TTD target and drug entries to the corresponding pathway entries of KEGG [15], MetaCyc/BioCyc [19], NetPath [20], PANTHER pathway [21], PathWhiz [22], Pathway Interaction Database (PID) [23], Reactome [24] and WikiPathways [25].

Results

Conclusion