Abstract
Obesity is a chronic metabolic and noncommunicable disease that affects 50% of world population. Reactive oxygen species and oxidative stress are interconnected with the obesity and several metabolic disorders, gaining the attention of scientific community to combat this problem naturally. Among various fruits, mango as a yellow fruit is rich in polyphenols, carotenoids, terpenes, and flavonoids that act as antioxidants to protect against free radicals produced in the body. The present study was performed to explore in vivo antioxidant potential of mango peels against dyslipidemia and oxidative stress in overweight subjects. The female volunteers (n = 31) between 25 and 45 years of age having a body mass index (BMI) of 25.0-29.9 (overweight) were included in this study, while participants with complications as diabetes, hypertension, cardiovascular, and liver diseases were excluded. The treatment group consumed 1 g mango peel powder for 84 days. The subjects were analyzed for biochemical analysis, antioxidant status, and anthropometric measurements at baseline and end of the study period. Further, at the end of study, the safety evaluation tests were also performed. The results showed that upon consumption of mango peel powder, low-density lipoproteins (LDL), cholesterol, triglyceride, urea, and creatinine levels were decreased and high-density lipoprotein (HDL) level was increased (P ≤ 0.05), while thiobarbituric acid reactive substances (TBARS) showed increased antioxidant status (P ≤ 0.05) which suggests that mango peels have a strong management potential against oxidative stress and dyslipidemia in obese subjects.
Highlights
Obesity is a chronic disease characterized by accumulation of fat in adipose tissues resulting in increased body weight [1, 2]
The mango peel extract was prepared from mango peel powder (MPP) according to the method followed by Tunchaiyaphum et al [15]
It was observed that mango peel extract contained an effective amount of vitamin C (49.52 ppm) along with a significant amount of kaempherol, chlorogenic acid, and gallic acid
Summary
Obesity is a chronic disease characterized by accumulation of fat in adipose tissues resulting in increased body weight [1, 2]. It is considered a frequent metabolic disease, having 50% prevalence among adult masses throughout the world [3]. Mango peel is an important part of the fruit considered inedible, rich in flavonoids, polyphenols, and carotenoids as antioxidants. It is about 15–20% of the fruit weight and is a major waste material of fruit processing sector [13].
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