Abstract
In a mathematical model we show that the dynamical multi-stability of a network of bursting subthalamic neurons, caused by synaptic plasticity, has strong impact on the stimulus-response properties when exposed to desynchronizing coordinated reset (CR) stimulation. Such stimuli can reliably shift the network from a stable state with pathological synchrony and connectivity to a stable desynchronized state with down-regulated connectivity.
Highlights
Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Don H Johnson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2202-10-S1-info.pdf
In a mathematical model we show that the dynamical multi-stability of a network of bursting subthalamic neurons, caused by synaptic plasticity, has strong impact on the stimulus-response properties when exposed to desynchronizing coordinated reset (CR) stimulation
The desynchronizing stimulation protocol is tested in two experimental setups: first, we studied longlasting effects of CR stimulation in rat hippocampal slice rendered epileptic by magnesium withdrawal
Summary
Eighteenth Annual Computational Neuroscience Meeting: CNS*2009 Don H Johnson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2202-10-S1-info.pdf . Therapeutic rewiring by means of desynchronizing brain stimulation Christian Hauptmann* and Peter A Tass Address: Neuromodulation, Institute for Neuroscience and Medicine, Juelich, Germany Email: Christian Hauptmann* - c.hauptmann@fz-juelich.de * Corresponding author
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