Abstract
Objectives: The lipid hypothesis was initially based upon Anitchkov's production of atherosclerosis in rabbits by diet-induced hypercholesterolaemia. Cessation of cholesterol feeding reversed the hypercholesterolaemia and reduced the severity of aortic lesions. Marked similarities exist between the location and composition of atheromatous plaques in this animal model and lesions in humans with FH. Retrospective analysis of angiographic trials suggests that cholesterol-lowering by statins and/or apheresis results in regression of coronary lesions in FH but only reduced their progression in non-FH subjects, despite similar percentage decreases in LDL-C.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
