Abstract
Kupipakwa Rasayanas are unique, widely prescribed, and highly therapeutic pharmaceutical preparations in ayurvedic therapeutics prepared in Kachkupi (glass bottle). Sameera Pannaga Rasa (SPR) is one such an arsenical compound formulation first cited in Rasa Chandanshu classic. It contains Parada (Hg), Gandhaka (S), Somala (As2O3), Haratala (As2S3), and Manahshila (As2S2) as integral components. Much diversity was seen in Rasa classics regarding its ingredients and duration of heating required for its preparation. Considering this, many studies have been carried out at different centers of India. The aim of the present study was to compile such available research works and relevant information from different Rasa classics and published literature from different databases to provide brief information about pharmaceutical, analytical, pharmacological, and clinical studies. Screening of literature revealed that Manahshila is not an ingredient of SPR in Rasa Chandanshu but added in recent treatises such as Ayurveda Aushadhi Guna Dharma Shastra and Ayurvedic Formulary of India. Totally seven references are found pertaining preparation of Sameer Pannaga Rasa in ayurvedic classics. It is recommended in the management of Tamaka Shwasa (bronchial asthma), Sandhivata (osteoarthritis), Amavata (rheumatoid arthritis), neurological disorders, etc.
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