Abstract

 
 
 
 Purpose: To evaluate the effects of M. quinquenervia extract on ethanol-induced peptic ulcer in rats.
 Methods: The following three groups of (n = 6) Sprague Dawley rats were included in this study: vehicle (C), ethanol-administered (E) and ethanol + M. quinquenervia-treated (MQ). MQ group rats received 100 μg/mL M. quinquenervia essential oil just before 96 % ethanol induction (1 ml/kg). One hour after ulcer induction, the animals were euthanized, and gastric and duodenal tissues were removed. Tissue samples were analysed for myeloperoxidase (MPO) activity, malondialdehyde (MDA), glutathione (GSH), myeloperoxidase (MPO) activity, malondialdehyde (MDA) and glutathione (GSH) levels, and histopathological examinations were performed by light microscopy.
 Results: Gastric and duodenal GSH levels that decreased in the ethanol-administered ulcer groups (p < 0.001), rose following MQ treatment (p < 0.5). Moreover, elevated MPO and MDA levels (p < 0.5) in gastric tissues decreased after MQ-treatment. Similarly, the MQ-treated group showed recovery and control-like morphology compared to the ethanol group in both gastric and duodenal tissues when examined by microscopy.
 Conclusion: The results indicate that M. quinquenervia extract has a positive impact on gastric injury in rats due to its antioxidant activity. Thus, the plant has a potential for the clinical management of gastric ulcer.
 
 
 
Highlights
IntroductionIts leaves are mostly used in the treatment of respiratory diseases [1]
Melaleuca quinquenervia is a small-to-mediumsized tree from the Myrtacae family
Ethanol administration resulted in the depletion of gastric and duodenal GSH levels (p < 0.001), while M. quinquenervia treatment reversed this depletion significantly (p < 0.5) (Figure 1 a and b)
Summary
Its leaves are mostly used in the treatment of respiratory diseases [1]. Acute gastric injury is a very common problem of the gastrointestinal tract, affecting an average of 4 million people per year. Its treatment is still being investigated [5]. Helicobacter pylori has a significant effect on the etiology and treatment of the disease, there is an increase in the incidence of gastric ulcers because of stress, alcohol consumption, and non-steroidal antiinflammatory drugs [6]. While omeprazole and similar anti-acid drugs, H2 receptor blockers, that are a class of gastric acidsuppressors like ranitidine and anticholinergics are frequently used in gastric diseases, they have many side effects and are insufficient to treat ulcer effectively [7]
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