Therapeutic potential of curcumin against lead-induced toxicity: A review

Ezamin Abdul Rahim,Maryam Muhammad Mailafiya,Abubakar Danmaigoro,Md Zuki A Bu Bakar,Abubakar Kabeer

doi:10.15419/bmrat.v6i3.528

Abstract

Lead poisoning causes numerous clinical implications in almost all organs, with the brain, liver, and kidneys serving as the primary targets due to the abundant presence of mitochondria. Curcumin is one of the most potent constituents of Curcuma longa, which is lipophilic, phenolic and water insoluble. Curcumin is a strong antioxidant and anti-inflammatory agent in the treatments of neurodegenerative disease, cardiovascular, renal, and liver diseases, with a potential anticancer mechanism in a few clinical and experimental trials. This review will focus on the health impact of lead-induced toxicity in different organ-systems, which occurs as result of increased oxidative stress through the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and will discuss the therapeutic potential of curcumin against lead-induced toxicity in both human and animals.

Highlights

Lead toxicity is a common public health threat in developing countries due to human activities such as mining and farming 1
This review will focus on the health impact of lead-induced toxicity in different organ-systems, which occurs as result of increased oxidative stress through the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and will discuss the therapeutic potential of curcumin against lead-induced toxicity in both human and animals
Curcumin antioxidant mechanism is executed in different patterns, which may include free radicals scavenging of reactive nitrogen species (RNS) and reactive oxygen species (ROS) as well as increasing the activity of serum enzymes such as GSH, catalase, and super oxide dismutase (SOD) that could result in the activation of inflammatory responses 5 (Figure 5)

Summary

Introduction

Lead toxicity is a common public health threat in developing countries due to human activities such as mining and farming 1. This review will focus on the health impact of lead-induced toxicity in different organ-systems, which occurs as result of increased oxidative stress through the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and will discuss the therapeutic potential of curcumin against lead-induced toxicity in both human and animals.

Results

Conclusion