Abstract
Accumulating evidence demonstrates that growing adipose tissues produce various pro-angiogenic factors, cytokines and adipokines, which induce neovascularization. Similar to malignant tissue growth, expansion of fat mass would not be achieved without switching on an angiogenic phenotype. Several recent studies using mouse genetic and high caloric diet-fed obese models validate this concept of preventing obesity by delivery of angiogenesis inhibitors. It is predicted, although it needs to be further proved, that antiangiogenic agents might be used either alone or in combinations with other existing therapeutic agents for the treatment of obesity. This review article focuses on discussing molecular mechanisms of angiogenesis in adipose tissues, defining vascular therapeutic targets, and employing antiangiogenic agents for prevention and treatment of obesity.
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