Therapeutic Potential and Nutraceutical Profiling of North Bornean Seaweeds: A Review.

Muhammad Shah,Wahidatul Zuldin,Yoong Yong,Sitti Shaleh,Charles Gnanaraj,Balu Venmathi Maran

doi:10.3390/md20020101

Muhammad Shah, Wahidatul Zuldin + Show 4 more

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https://doi.org/10.3390/md20020101

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Abstract

Malaysia has a long coastline surrounded by various islands, including North Borneo, that provide a suitable environment for the growth of diverse species of seaweeds. Some of the important North Bornean seaweed species are Kappaphycus alvarezii, Eucheuma denticulatum, Halymenia durvillaei (Rhodophyta), Caulerpa lentillifera, Caulerpa racemosa (Chlorophyta), Dictyota dichotoma and Sargassum polycystum (Ochrophyta). This review aims to highlight the therapeutic potential of North Bornean seaweeds and their nutraceutical profiling. North Bornean seaweeds have demonstrated anti-inflammatory, antioxidant, antimicrobial, anticancer, cardiovascular protective, neuroprotective, renal protective and hepatic protective potentials. The protective roles of the seaweeds might be due to the presence of a wide variety of nutraceuticals, including phthalic anhydride, 3,4-ethylenedioxythiophene, 2-pentylthiophene, furoic acid (K. alvarezii), eicosapentaenoic acid, palmitoleic acid, fucoxanthin, β-carotene (E. denticulatum), eucalyptol, oleic acid, dodecanal, pentadecane (H. durvillaei), canthaxanthin, oleic acid, pentadecanoic acid, eicosane (C. lentillifera), pseudoephedrine, palmitic acid, monocaprin (C. racemosa), dictyohydroperoxide, squalene, fucosterol, saringosterol (D. dichotoma), and lutein, neophytadiene, cholest-4-en-3-one and cis-vaccenic acid (S. polycystum). Extensive studies on the seaweed isolates are highly recommended to understand their bioactivity and mechanisms of action, while highlighting their commercialization potential.

Highlights

Publisher’s Note: MDPI stays neutralMarine organisms have been widely used as sources of functional bioactive compounds over the years [1]
Seaweeds are divided into three groups—green algae (Chlorophyceae), red algae (Rhodophyceae), and brown algae (Phaeophyceae) [3]—and possess a wide range of biological potentials that are beneficial against several disorders such as cytotoxic, antioxidant, anti-inflammatory, and antimitotic activities [4,5]
The results indicated that the methanol extract inhibited the growth of B. subtilis (6.5 mm) and S. aureus (7.5 mm)

Summary

Introduction

Marine organisms have been widely used as sources of functional bioactive compounds over the years [1]. Seaweeds (multicellular marine algae) are well-documented natural sources of proteins, nitrogen compounds, carbohydrates as well as lipids, vitamins, minerals, pigments and volatile compounds [1,2]. Seaweeds are divided into three groups—green algae (Chlorophyceae), red algae (Rhodophyceae), and brown algae (Phaeophyceae) [3]—and possess a wide range of biological potentials that are beneficial against several disorders such as cytotoxic, antioxidant, anti-inflammatory, and antimitotic activities [4,5]. Fast industrial growth, and the public’s desire for natural products, worldwide demand for seaweed products is anticipated to grow even more in the years ahead [6]. The with regard to jurisdictional claims in published maps and institutional affiliations

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