Abstract
Objective: The objective of the study was to evaluate the therapeutic potential and in vitro anthelmintic activity of ridge gourd fruit (Luffa acutangula) against Indian earthworms.
 Methods: For anthelmintic activity against Indian earthworms (Pheretima posthuma, Ascaridia galli, and Raillietina spiralis), various different extracts concentration of L. acutangula fruit have been taken. Five concentrations as 10, 20, 30, 40, and 50 mg/ml of various extracts were tested and results were expressed in terms of time for paralysis and time for the death of worms. Albendazole (20 mg/ml) was used as reference standard and water (0.5%) as a control group.
 Results: Preliminary phytochemical screening of the different extracts of ridge gourd fruit was shown to produce anthelmintic activities. In the present study, it was observed that all the extracts of ridge gourd fruit have exhibited a positive response to a certain degree of anthelmintic activity. Ethyl acetate extract exhibited more potent activity at the lower concentration of 10 mg/mL against A. galli (Roundworm). The anthelmintic activity of L. acutangula fruit extract has, therefore, been demonstrated.
Highlights
Helminthiasis is the most common infection caused by worms that is a contaminant to human body parts [1,2,3], and its one of the most prevalent infections; children are often infected with several species and a degenerative disease that affects a large percentage of the population in the worldwide
As our ongoing work for a search of new drug [22,23,24,25], we have focusing in booth synthetic and nature products. Keeping in mind such astounding properties exhibited by this plant, the present study was intended to investigate the anthelmintic activity of ethyl acetate extract of ridge gourd fruit in the Indian earthworm
It was observed that all the extracts of ridge gourd fruit have exhibited a positive response to a certain degree of anthelmintic activity
Summary
Helminthiasis is the most common infection caused by worms that is a contaminant to human body parts [1,2,3], and its one of the most prevalent infections; children are often infected with several species and a degenerative disease that affects a large percentage of the population in the worldwide. Luffa acutangula (family: Cucurbitaceae) referred to as ridge gourd, angled or angled luffa (Fig. 1), is one of Asia’s potential herbs It is a common vegetable grown in India, China, Southeast Asia, Egypt, Japan, and other African countries, which has a various pharmacological activities includes antidiabetic activity [10,11], antioxidant activity, hepatoprotective activity [12], central nervous system [13], anticancer [14,15], and fungistatic property [16]. As our ongoing work for a search of new drug [22,23,24,25], we have focusing in booth synthetic and nature products Keeping in mind such astounding properties exhibited by this plant, the present study was intended to investigate the anthelmintic activity of ethyl acetate extract of ridge gourd fruit in the Indian earthworm
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