Abstract
Owing to a dramatic increase in average life expectancy, most countries in the world are rapidly entering an aging society. Therefore, extending health span with pharmacological agents targeting aging-related pathological changes, are now in the spotlight of gerosciences. Panax notoginseng (Burk.) F. H. Chen, a species of the genus Panax, has been called the "Miracle Root for the Preservation of Life," and has long been used as a Chinese herb with magical medicinal value. Panax notoginseng has been extensively employed in China to treat microcirculatory disturbances, inflammation, trauma, internal and external bleeding due to injury, and as a tonic. In recent years, with the deepening of the research pharmacologically, many new functions have been discovered. This review will introduce its pharmacological function on lifespan extension, anti-vascular aging, anti-brain aging, and anti-cancer properties, aiming to lay the ground for fully elucidating the potential mechanisms of Panax notoginseng’s anti-aging effect to promote its clinical application.
Highlights
With a dramatic increase in life expectancy, most countries are entering an aging society
Apart from these, extractions of Panax notoginseng (EPN) could enhance the actions of 5-fluorouracil and irinotecan on SW480 cells, suggesting that Panax notoginseng can reduce the needed dose of chemotherapeutic agents to achieve desired effects. These results indicate that EPN may provide significant natural defense against human cancer via inhibiting cell proliferation and promoting cell apoptosis by regulating distinct molecules
Notoginsenoside R1 (NR1) inhibited Aβ accumulation and increased insulin degrading enzyme expression in both amyloid precursor protein (APP)/PS1 doubletransgenic mice and N2a-APP695sw cells, suggesting that NR1 may exert its protective effects through the enhancement of Aβ degradation and the effect of NR1 was partly mediated by PPARγ [107]
Summary
With a dramatic increase in life expectancy, most countries are entering an aging society. How to delay aging and to prevent cell senescence-associated diseases has become a hotspot of research all over the world. Three major species most extensively researched and used worldwide for thousands of years as either food or medicine are, Panax notoginseng (Burk.) F.H. Chen (notoginseng), Panax ginseng C.A. Meyer (Asian ginseng) and Panax quinquefolius (American ginseng) [3]. Prevention of aging by Panax Notoginseng pathological processes that lead to a progressive functional decline in cells, tissues, and organisms. Panax notoginseng is a unique botanical plant since its cultivation strictly follows the GAP guidelines [14] It has been widely used for over 400 years and still holds a unique position in today’s regional market, with remarkable annual sales of 5000 tons in China alone
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