Therapeutic Peptides in Skin and Hair Disorders

Abstract

AbstractProtein therapeutics are a relatively new subset of medicinal treatment whose application, while still in its infancy, has demonstrated its significance in almost all fields of medicine. Due to its clinical success, it has an unmatched value in modern medicine. Advances in synthetic chemistry and molecular biology have increased the utility of peptides in therapeutics. These proteins and peptides have demonstrated their importance in treating a broad spectrum of disorders, including fatal diseases such as cancer, metabolic disorders, and autoimmune diseases. Many of these peptides also have the potential to be used for their cosmetic value in addition to their therapeutic properties in the treatment of various skin and hair disorders, if they can be administered effectively to target sites within these organs. Natural as well as synthetic, peptides are frequently used as anti-aging ingredients in cosmetics. Wrinkle reduction requires targeted cellular and molecular intervention in conjunction with effective topical therapy. Enhancing the skin’s barrier function and manipulating the melanogenesis process to achieve sunless tanning or pigment reduction are two additional cosmetic applications where peptides may be advantageous. Hair loss is becoming increasingly prevalent in the community. Due to the negative impact on self-esteem and despair, treatments aimed at minimizing the appearance of thinning hair by delaying, halting, or reversing the problem of hair development are necessary. The development of biotechnology substances that mimic growth factors has enabled the development of novel treatment techniques. The use of bioactive peptides generated via biotechnological techniques has also aided in resolving PRP’s hair growth limitations. On the other hand, it has been demonstrated that the use of bioactive collagen peptides helps to promote nail development. Further advances in the fields of protein therapeutics may open up a plethora of new treatment options for cutaneous disorders.KeywordsGrowth factorscosmeceuticalsAntimicrobial peptidesAlopeciaPARP