Abstract
Background and Aims: Arterial stiffness is a hallmark of vascular aging that precedes and predicts the development of cardiovascular diseases. Age-dependent arterial stiffness is primarily attributed to increased levels of matrix metalloproteinase-2 (MMP-2). However, the mechanistic link between age-dependent arterial stiffness and MMP-2 remains unclear. Thus, we investigated the efficacy of therapeutic MMP-2 knockdown using small interfering RNA (siRNA) on age-dependent arterial stiffness.
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