Abstract
Therapeutic is a problem for all research aimed at developing treatments for human diseases. The term therapeutic misconception was originally coined in 1982 to describe a fundamental confusion among research subjects and researchers alike between the goals of research (generalisable knowledge) and the goals of clinical care (improving the health of an individual patient)1. However, the phenomenon was recognised and documented as a set of misunderstandings among research subjects about scientific methods such as randomisation and placebo controls, and of underestimation of risk and overestimation of benefit of participating in medical research. The latter is now sometimes distinguished as therapeutic misestimation.
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