Abstract
AbstractBackgroundAlpha napthoflavone (ANF) is a flavonoid compound it is also know as Alpha‐ 7,8‐benzoflavone, it is a natural flavone available in Russian knapweed in larger quantity. Pharmacologically, it is also reported to produce the cardioprotection, neuroprotection including anti‐Alzheimer actions. It possesses multiple cellular actions like anti‐oxidant, anti‐inflammatory, and anti‐apoptotic actions. However, the role of ANF in vascular dementia (VaD) not explored yet.MethodVaD was induced by i.c.v. injection of L‐Cys in rats. The test compounds i.e., ANF (40 and 80 mg/kg; p.o.) and reference drug i.e., donepezil (10 mg/kg; p.o.) were administered for 5 consecutive days. The behavioral assessment i.e., learning and memory functions were evaluated by Morris water maze (MWM) test. In addition, the biochemical markers i.e., acetylcholinesterase (AChE) activity; lipid peroxidation (LPO) and homocysteine (HCy) levels were estimated in hippocampal tissue samplesResultANF shown ameliorative effect against i.c.v. injection of L‐Cys induced VaD in rats via reduction of AChE activity, LPO and HCy levelsConclusionANF may be a newer candidate from herbal origin for the management of cerebrovascular disorders like stroke and vascular dementia.
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