Abstract
Curcuma longa or turmeric is a plant that is used as a spice and as a phytoconstituent in many formulations from Vedic age. Curcuminoids are the most important Phyto constituents present in turmeric with various pharmacological activities. The present study reveals various pharmacological activities of curcumin with special emphasis on MDR cancer cells. The curcuminoids are the Phyto constituents showing potent activity against neurological disorders, cardio vascular diseases, auto immune disorders, Metabolic disorders, cancer, inflammatory diseases, Skin allergies and disorders. This review give emphasis on anticancer activity of curcumin and its possible mechanism of actions. Many studies revealing that various formulations and combination therapy of curcumin is increasing its bioavailability and there by effective against various diseases. This review is lighting to a treasure buried inside the soil a potential therapeutic agent without side effects.
Highlights
Turmeric was used as a functional food and as a home remedy for different diseases from the ancient period in India and was prepared from the plant Curcuma longa (Orellana-Paucar et al, 2013)
This study shows that phospholipidated curcumin capsules with 100mg of curcumin for 8 days can reduce Non-Alcoholic Fatty Liver Disease (NAFLD) severity (Panahi et al, 2019)
Curcuma longa or turmeric is a plant with an abundant treasure of medicinal values that should be selected for further research because of its proven activity against various diseases
Summary
Turmeric was used as a functional food and as a home remedy for different diseases from the ancient period in India and was prepared from the plant Curcuma longa (Orellana-Paucar et al, 2013). Curcumin inhibits the mechanism of the P-gp/ABCB1 protein in cervical cancer cells by engaging with the P-gp binding site on the cell surface and by connecting with the P-gp active sites, resulting in a considerable reduction in the mechanism of this transporter When these cells are treated with curcumin and vinblastine, vinblastine accumulates within the cells and thereby increasing the sensitivity of the cells (Limtrakul, Anuchapreeda and Buddhasukh, 2004; Zhang et al, 2014). In a study using A549- human lung cancer cell lines novel curcumin-loaded mixed micelles were prepared by using the solvent evaporation method to increase the oral bioavailability and cytotoxicity and the results revealed that a significant improvement in oral bioavailability and cytotoxic action of curcumin formulation as compared to curcumin. Silicon dioxide/triacetin/Panadon 9 fold (Jäger et al, 2014)
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