Abstract
Summary The inactivation of gentamicin serum in and intravenous infusion fluids by various penicillins and cephalosporins has been investigated. At therapeutic concentrations no significant inactivation occurred in serum at 37°C, but in the infusion fluids large therapeutic doses of carbenicillin and ampicillin produced a rapid fall in measurable gentamicin concentrations at room temperature. It is nevertheless concluded that the in-vitro inactivation of gentamicin is not a contraindication to the combined use of gentamicin and a penicillin or cephalosporin antibiotic in the treatment of serious sepsis, provided that they are not mixed in intravenous infusion fluids. Where large doses of a penicillin are being administered by continuous intravenous infusion it is recommended that gentamicin should be given by intramuscular or "bolus" intravenous injection.
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