Abstract
Objective: The aim of the present study is to investigate the effect of Morus alba (MA) and Morus rubra L. (MR) fruit extract on obesity-induced cardiac dysfunction and fibrosis in cardiac tissue.Methods: Seventy male Wistar albino rats were randomly divided into five groups of ten rats each. MA and MR have been administered for 6 weeks in obese rats induced by high-fat diet (HFD). Adiponectin, glucagon, troponin, plasminogen activator inhibitor, cell adhesion molecules-1 (intracellular and vascular respectively), C-reactive protein, collagen type II and collagen alpha-1 (III) chain, and lipoxygenase activity were also estimated in serum of obese rats. Histopathological investigation of cardiac tissue was carried out.Results: MA and MR treatments significantly normalized cardiac dysfunction biomarkers as well as cardiac fibrosis as examined by histopathological examination with higher percentage of improvement for MR extract.Conclusion: Hence, it could be concluded that MA and MR extracts have useful effects on obesity-associated cardiac diseases through lipid metabolism regulation, cardiac functions and reversed cardiac fibrosis.
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