Abstract
Induced hypothermia or targeted temperature management has been studied as a potential therapy for improving outcome following traumatic brain injury (TBI) and to a lesser extent, spinal cord injury (SCI). Hypothermia has been clearly demonstrated to improve clinical outcome following cardiac arrest. Preclinical TBI models have shown efficacy. Unfortunately, to date, this is not true for clinical moderate to severe TBI in humans. The same is true for spinal cord injury (SCI). As a result, there is insufficient evidence to support the routine use of induced hypothermia for improving outcome following TBI or SCI. The one clinical condition for which induced hypothermia may be useful is reducing elevated intracranial pressure (ICP) that is recalcitrant to standard medical therapy.
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