Therapeutic failure in moderate and severe psoriasis patients in a health institution – a transversal study of prevalence and demographic determinants

Abstract

Background Psoriasis is a chronic disease that seriously impacts quality of life. There are known genetic and environmental factors that influence its onset and progression. Even though there is no cure for it, there are a variety of treatments available today to control its symptoms, although many of them fail to do so substantially. Objective To identify the association of multiple sociodemographic, clinical, and pharmacological factors with therapeutic failure. Methods Observational, descriptive, cross-sectional, retrospective, and analytical study of therapeutic failure in patients with moderate or severe psoriasis between 2020 and 2021 was performed. Results In total 1051 patients with moderate or severe psoriasis were evaluated. Gender (ORa: 0.579 CI 95%: 0.382–0.878), type of therapy (biologic or non-biologic; ORa: 1.939 CI 95%: 1.242–3.027), age (ORa: 1.018 CI 95%: 1.003–1.034), days of treatment (ORa: 1 CI 95%: 0.999–1) and DLQI (ORa: 1.212 CI 95%: 1.172–1.253) are significantly associated with therapeutic failure. Conclusion Being male and receiving biologic therapy are associated with a higher incidence of therapeutic failure in the treatment of moderate or severe psoriasis. The increase in DLQI increase in the probability of failure, and mayor age or days of treatment decrease in the probability of failure.