Abstract
Objective: To observe the curative effects of Yiqing granule and Zhibai Dihuang pill combined with Oralpolin gel on recurrent aphthous ulcer. Methods: 150 patients with mild recurrent aphthous ulcer were classified as excessive internal heat type and deficiency internal heat type by traditional Chinese medicine theory. Then, they were randomly divided into the positive control group (thalidomide group), the trial group (Yiqing granule group/Zhibai Dihuang pill group), and the negative control group (topical medication group). All the patients in every group used Oralpolin gel. Additionally, the patients in the positive control group took thalidomide tablets orally and those in the trial group orally took proprietary Chinese medicine (Yiqing granule/Zhibai Dihuang pill). The treatment lasted for 4 weeks. The curative effects were all evaluated according to the “RAU Efficacy Evaluation Trial Standard” which was formulated by the Professional Committee of Mucosal Diseases of Chinese Stomatological Association. Results: Of all the 150 patients involved in this medical experiment, 146 cases finished it, including 66 ones in the trial group, 36 ones in the positive control group, and 44 ones in the negative control group. The total drop-out rate was 2.7%. For the excessive internal heat type, the effective rates in the thalidomide group, the Yiqing granule group and the local medication group were 91.7%, 52.6% and 52.9% respectively in order. For the deficiency internal heat type, the effective rates in the thalidomide group, the Zhibai Dihuang pill group and the local medication group were 87.5%, 71.4% and 40% respectively in order. The clinical efficacy of the Zhibai Dihuang pill group was better than that of the local medication group and similar to that of the thalidomide group (P < 0.05). Conclusion: Zhibai Dihuang pill is significantly effective in the treatment for mild recurrent aphthous ulcer of deficiency internal heat type without severe adverse reactions.
Highlights
Recurrent aphthous ulcer (RAU), known as recurrent oral ulcer (ROU) or recurrent aphthous stomatitis (RAS), generally shows a round or oval shape, a sunken center, a surface covered with yellow-white pseudomembrane, and a flushed edge, and causes clearly-felt pains [1]
This study observed the efficacy of Zhibai Dihuang pill and Yiqing granule combined with Oralpolin gel in the treatment for recurrent aphthous ulcer of different TCM types, in order to provide a basis for the treatment for recurrent aphthous ulcer with the combination of traditional Chinese medicine and western medicine
A total of 150 subjects were included in this study, and 146 cases completed the experiment. 1 case shed among the 37 cases in the positive control group and the shedding rate was 2.7%; 1 case shed among the 67 cases in the experimental group and the shedding rate was 1.5%; 2 cases shed among the 46 cases in the negative control group and the shedding rate was 4.3%; the total shedding rate was 2.7% (
Summary
Recurrent aphthous ulcer (RAU), known as recurrent oral ulcer (ROU) or recurrent aphthous stomatitis (RAS), generally shows a round or oval shape, a sunken center, a surface covered with yellow-white pseudomembrane, and a flushed edge, and causes clearly-felt pains [1]. It is the most common oral mucosal ulcer disease, and its incidence among the population can reach 10% 25%. This study observed the efficacy of Zhibai Dihuang pill and Yiqing granule combined with Oralpolin gel in the treatment for recurrent aphthous ulcer of different TCM types, in order to provide a basis for the treatment for recurrent aphthous ulcer with the combination of traditional Chinese medicine and western medicine
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