Therapeutic efficiency of naoxintong capsule on the patients with moderate obstructive sleep apnea hypopnea syndrom of cognitive dysfunction

Abstract

Objective To observe the therapeutic efficiency of naoxintong capsule on the patients with moderate obstructive sleep apnea hypopnea syndrom(OSAHS) of cognitive dysfunction. Methods Sixty patients of moderate OSAHS were randomly divided into treatment group and control group, 30 cases in each group.Patients in the treatment group were given naoxintong capsule, three goals, three times a day, at the same time, with double level positive pressure ventilation therapy for 3 months.Patients in the control group accepted double level positive pressure ventilation therapy for 3 months.The questionnaires of Montreal Cognitive Assessment(MoCA) were administered to assess cognitive in all the patients before and after treatment. Results There was no statistically significant difference in term of MoCA score between the two groups before treatment(t=0.14, P>0.05). After treatment, the MoCA score of the treatment group was (25.83+ 1.70), of control group was (22.70+ 2.51), the difference was statistically significant(t=5.62, P<0.05). The visual space and executive function, naming, attention, language, abstract, delayed recall and directional score in the treatment group after treatment were (5.03±0.81) points, (2.90±0.31) points, (4.73±0.58) points, (2.63±0.49) points, (1.97±0.18) points, (3.93±0.98) points, (5.03±0.56) points respectively, compared with before treatment((4.07±0.79) points, (2.17±0.59) points, (3.40±0.50) points, (2.03±0.49) points, (1.80±0.41) points, (2.87±0.73) points, (4.03±0.77) points), the differences were statistically significant (t=6.55, 6.89, 13.36, 5.29, 2.41, 4.87, 6.60; P<0.05). The naming, attention, language, abstract, delayed recall and directional score in the control group after treatment were (2.77±0.43) points, (4.07±0.75) points, (2.20±0.55) points, (1.87±0.35) points, (3.10±0.66) points, (4.67±0.71) points respectively, ompared with before treatment((2.30±0.65) points, (3.43±0.68) points, (2.00±0.70) points, (1.73±0.45) points, (2.93±0.58) points, (3.93±0.69) points), the differences were statistically significant(t=5.04, 4.34, 2.26, 2.11, 2.41, 6.28; P<0.05). MoCA score in treatment group than the control group have improved significantly in visual space and executive function, attention, language and delayed recall, directional (t=4.51, 3.80, 3.22, 3.86, 2.23, P<0.05). Conclusion Naoxintong capsule can improve cognitive dysfunction in patients with moderate OSAHS. Key words: Naoxintong capsule; Obstructive sleep apnea hypopnea syndrome; Cognitive dysfunction