Abstract
The objective of this study was to assess the short-term effect of plasmonic photothermal therapy (PPTT) on induced hamster buccal pouch (HBP) carcinoma. Seventy-six Syrian golden male hamsters were used. The induced HBP carcinomas were directly injected with ∼30nm gold nanospheres followed by 15min laser exposure (PPTT). PPTT caused rapid growth cessation and dramatic decrease in tumor sizes after 4weeks of treatment (P<.05) compared to controls. Microscopic and immunohistochemical examination of the tumor biopsies revealed significant differences in the cellular apoptotic index (AI) value and proliferating cell nuclear antigen (PCNA) immunoexpression in PPTT-treated tumor tissue sections compared to controls (P<.05). Survival probability of the treated animals was increased compared to controls (P<.05). PPTT proved to be a successful method for treating superficially located HBP carcinomas.
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