Therapeutic efficacy of paroxetine and influence on inflammatory markers in elderly acute myocardial infarction patients with anxiety and depression

Abstract

Objective To investigate the therapeutic efficacy of paroxetine and influence on inflammatory markers in elderly acute myocardial infarction(AMI) patients with and depression. Methods 136 patients with AMI graded by the hospital depression and anxiety score were divided into three class: ⑴patients with (n=54); ⑵Patients with depression (n=39); ⑶Patients with and depression (n=43).136 patients were randomly divided into paroxetine group(paroxetine 10-20 mg/d)and conventional group (conventional drugs based on guidelines). After 28 days treatment, HAD scores, serum level of inflammatory markers(Hs-CRP, MPO, and cTnI ) were compared between two groups. Results ⑴HAD scores(HADa and HADd)of paroxetine group were decreased significantly after 28 days treatment(P<0.01); while there were no remarkable improvements in conventional group.With paroxetine treatment HAD scores of anxiety, depression, and depression(10.52±2.74, 10.83±3.25, 9.49±2.57, 9.99±2.38) were much lower than those of conventional group(P<0.05). ⑵Serum Hs-CRP, MPO and cTnI of paroxetine group in patients with were much lower than those of conventional group (P<0.05). Serum Hs-CRP, MPO and cTnI of paroxetine group in patients with depression were much lower than those of conventional group (P<0.05). Serum Hs-CRP, MPO and cTnI of paroxetine group in patients with and depression were much lower than those of Conventional group (P<0.05). Conclusion Paroxetine has remarkable treatment effect in elderly AMI patients with and depression, and paroxetine call significantly decreased serum levels of inflammatory markers. Key words: Acute myocardial infarction; Elderly; Anxiety; Depression; Inflammatory markers; Paroxetine