Abstract
Aim: The current study was done to study the therapeutic effect of natural prostaglandin in treatment of canine pyometra. Materials and Methods: Seven bitches were treated with natural PGF · i.e. dinoprost tromethamine at the dose rate of 100 2 µg/kg body weight subcutaneously once daily for 7 days with supportive therapies. The physiological, haematological and th th biochemical parameters were studied before (0 day) and after treatment (8 day). Therapeutic efficacy was assessed in terms of return of abnormal parameters to either normal or near normal value as compared to the untreated control group, intensity of side effects and post treatment reproductive status. Results: All physiological, haematological and biochemical parameters in the seven treated bitches returned to normal range at the end of treatment. The intensity of side effects was quite severe in the treatment group. Six bitches came to estrus within 2 months of treatment and out of them four conceived on subsequent mating. In rest three bitches there was recurrence of pyometra within 4 months of treatment. Conclusion: Though conception rate of recovered bitches is decreased when compared with that of normal healthy bitches still this treatment protocol can be used successfully in treatment of canine pyometra to conserve the breeding capability of bitches.
Highlights
Pyometra is the accumulation of purulent material occurred within the lumen of the uterus in intact bitches [1] which was reported to induce high mortality in bitches if not treated [2]
Immediate breeding of the treated bitches during the estrus is recommended to prevent the recurrence [8]
Treatment response: All the seven bitches were successfully treated by using natural PGF2α (Dinoprost tromethamine) at the dose rate of 100 μg/kg body weight once daily for 7 days subcutaneously along with supportive therapy (100 per cent recovery rate) which resulted in disappearance of externally visible clinical signs of pyometra
Summary
Pyometra is the accumulation of purulent material occurred within the lumen of the uterus in intact bitches [1] which was reported to induce high mortality in bitches if not treated [2]. It is recognized as one of the main causes of disease and death in the bitch [3]. In order to conserve the breeding capability of valuable females, medical treatment can be attempted which usually involved the repeated administration of prostaglandins [5, 6] which causes lysis of the corpora lutea and a reduction in plasma progesterone concentration. As corpora lutea of bitches are relatively insensitive to the effects of administered prostaglan-
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