Abstract
Purpose: To investigate the clinical efficacy of thymosin combined with oxaliplatin and tiggio in aged gastric cancer (GC) sufferers, as well as their impact on cellular immunity and matrix metalloproteinase.Methods: Elderly GC sufferers (n = 82) were divided into study and control groups by random allocation (41 patients/group). Control group was treated with oxaliplatin combined with tiggio, while the study group was treated with thymopeptide injection, in addition to oxaliplatin combined with tiggio. Each treatment course lasted 21 days, and the study involved three courses. Clinical effectiveness and toxicity in the two groups were determined and compared before and after treatment.Results: Total effectiveness in the study group (73.16 %) and disease remission (95.11 %) were superior to the corresponding values for control patients given oxaliplatin and tiggio (48.78 and 85.37 %, respectively, p ˂ 0.05). There were markedly lower incidences of nausea, vomiting and leukopenia in the study group than in control (p ˂ 0.05).Conclusion: The use of thymosin-oxaliplatin-tigeo triple therapy for aged GC sufferers has a definite clinical benefits and low toxic side effects.Keywords: Thymosin, Asha Leigh Per, Teggio, Gastric cancer, Cellular immunity, Matrix metalloproteinase
Highlights
Gastric cancer, one of the malignant tumors of the digestive system kills about 700,000 people every year
In this study, the impact of combination treatment with thymosin, oxaliplatin and tiggio on aged gastric cancer (GC) sufferers was investigated with respect to cellular immunity, matrix metalloproteinase and endocrine function of tumors
The criteria for inclusion were as follows: (1) those who satisfied the conditions for diagnosis of gastric cancer [4], and were confirmed by pathological, cytological and imaging examinations; (2) patients in TNM stages III to IV; (3) patients aged over 60 years, and with expected survival time over 3 months; (4) patients with at least one lesion measured according to RECIST [5]; (5) patients with normal electrocardiogram, and normal heart, liver and kidney functions, in addition to those without chemotherapy contra-indications
Summary
One of the malignant tumors of the digestive system kills about 700,000 people every year. In this study, the impact of combination treatment with thymosin, oxaliplatin and tiggio on aged GC sufferers was investigated with respect to cellular immunity, matrix metalloproteinase and endocrine function of tumors. The criteria for inclusion were as follows: (1) those who satisfied the conditions for diagnosis of gastric cancer [4], and were confirmed by pathological, cytological and imaging examinations; (2) patients in TNM stages III to IV; (3) patients aged over 60 years, and with expected survival time over 3 months; (4) patients with at least one lesion measured according to RECIST [5]; (5) patients with normal electrocardiogram, and normal heart, liver and kidney functions, in addition to those without chemotherapy contra-indications. In order to give symptomatic treatment for toxic and side effects, the heart, liver and kidney functions were determined regularly.
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