THERAPEUTIC EFFICACY OF AMINOGLYCOSIDES AGAINST CRYPTOSPORIDIOSIS OF CALVES

Abstract

To treat calves for cryptosporidiosis, we used aminoglycosides containing paromomycin: the drugs "Protostop" and "Parofor 70". "Protostop" was administered orally in 3- and 5-day courses at a dose of 250 mg and 350 mg per 1 kg of the animal weight individually. A single dose of the drug was dissolved in water before use. "Parofor 70" was prescribed individually for 5 days at a dose of 350 mg per 1 kg of the animal weight, and dissolved in water before use. The efficacy was evaluated based on the reduction or absence of cryptosporidia in fecal samples on the 0, 8 and 12th day. It was found that "Protostop", which contains 100.0 mg of paromomycin sulfate in 1,0 g had a pronounced therapeutic effect on cryptosporidiosis of calves at a dose of 350 mg/kg of the animal weight in a 5-day course. "Protostop" used at a dose of 250 mg/kg and 350 mg/kg of the animal weight in 3- and 5-day courses did not have a negative side effect on the animal’s body. The therapeutic efficacy of "Protostop" used at a dose of 350 mg/kg of the animal weight orally with water, once a day, in a 5-day course was higher than the efficacy of "Parofor 70" used at a dose of 350 mg/kg in a similar course.