Therapeutic Efficacy of a Single Dose of Anti-D Immunoglobulin 50µg/kg in Childhood Acute Immune Thrombocytopenic Purpura

Abstract

Methods: We serially evaluated the platelet count in 21 acute ITP patients that were treated with anti-D immunoglobulin (50μg/kg) to determine how many patients achieved platelet counts over the levels of 20×10 3 /mm 3 , 50×10 3 /mm 3 and 100×10 3 /mm 3 after the infusion of anti-D immunoglobulin. In addition, constitutional symptoms were monitored and changes in the hemoglobin levels were serially evaluated. Results: By three days after treatment, 90.5% of the patients had achieved a platelet count over 20× 10 3 /mm 3 . At seven days after treatment, 66.7% of patients achieved a platelet count of 50×10 3 /mm 3 . In addition, at seven days after treatment 61.9% of patients achieved a platelet count of 100×10 3 /mm 3 . Constitutional adverse symptoms were observed 61.9% of patients, and the symptoms diminished spon- taneously without any severe sequelaes. The decline of hemoglobin concentration after treatment recovered to the initial level after two weeks. Conclusion: A single dose of anti-D immunoglobulin (50 μg/kg)was effective in Korean children with acute ITP to raise the platelet count rapidly. The adverse effects of anti-D immunoglobulin, including hemolytic anemia, were not severe to prevent the use of the anti-D. (Korean J Hematol 2007;42:258-263.)