Abstract
The article presents the results of studying the therapeutic efficacy of the complex drug tsipropig based on recombinant porcine interferons for Actinobacillus pleuropneumonia of piglets at an industrial pig-breeding complex and its effect on nonspecific immunity. It has been found that the drug has pronounced therapeutic properties and an immunomodulatory effect due to the presence of the fluoroquinolone antibiotic ciprofloxacin in the composition of tsipropig, the immunocorrective activity of its constituent recombinant porcine interferons alpha and gamma and vitamins E and A possessing antioxidant properties.
Highlights
Actinobacillus pleuropneumonia (APP) is an infectious disease of pigs characterized by the development of hemorrhagic necrotizing pneumonia and serous fibrinous pleurisy caused by Actinobacillus pleuropneumoniae [1,2,3]
The lack of effective control over infectious diseases using antibacterial drugs determines the relevance of searching for alternative approaches, in particular based on modulating the immune response, since the development and course
During bacteriological examination of pathological material, the causative agent of Actinobacillus pleuropneumoniae was isolated from piglets with pneumonia slaughtered for diagnostic purposes, and its genome was found in molecular and biological research
Summary
Actinobacillus pleuropneumonia (APP) is an infectious disease of pigs characterized by the development of hemorrhagic necrotizing pneumonia and serous fibrinous pleurisy caused by Actinobacillus pleuropneumoniae [1,2,3]. Actinobacillus pleuropneumonia causes significant economic damage resulting from the high morbidity and mortality of piglets, reduced performance and product quality, as well as the cost of prevention and control of infection [2, 3]. The onset of the disease is facilitated by the weakening of the body's resistance due to various stress factors: early weaning of piglets from sows, regrouping and transportation of animals, hypothermia or overheating of the body, veterinary and zootechnical measures [24]. The empirical use of antimicrobial agents for the treatment of bacterial infections has led to the emergence of multidrug-resistant microbes that reduces the efficacy of etiotropic therapy of infectious diseases [5, 6].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
