Abstract

 
 
 
 Purpose: To investigate the therapeutic effect of ulinastatin on postoperative complications and cognitive function in elderly patients with esophageal cancer after thoracic laparoscopic surgery.
 Methods: A total of 100 elderly in-patients with esophageal cancer who had undergone thoracic laparoscopic surgery from April 2019 to December 2020 were selected and randomly assigned to control and study groups. Patients in control group received conventional treatment, while those in the study group were administered ulinastatin. The two groups were compared with respect to response, incidence of postoperative complications, Mini-Mental State Examination (MMSE) cognitive function score, Barthel Index (BI) scores; preoperative, intraoperative, 12-h and 24-h post-surgery levels of IL-1β and IL-6; levels of CD3+, CD4+ and CD8+, as well as duration of surgery and waking time.
 Results: Response, MMSE score, BI index, and levels of CD3+, CD4+ and CD8+ in the study group were significantly higher than those in the control group (p < 0.05). Incidence of postoperative complications, and expression levels of IL-1β and IL-6 12 h and 24 h after surgery in the study group were lower than the corresponding control levels (p < 0.05). There were no significant differences in duration of operation and waking time between the two groups (p > 0.05).
 Conclusion: Ulinastatin significantly reduces postoperative complications, and also improves cognitive function in elderly patients with esophageal cancer after thoracic laparoscopic surgery. This finding is of great significance in the treatment of these patients.
 
 
 
Highlights
Esophageal cancer is a disease of the digestive system with increasing incidence, mostly among the elderly population
The response, incidence of complications, cognitive function, inflammatory factors and immune function were compared between subjects who received conventional treatment and those who were given ulinastatin in addition to conventional therapy
It was found that the percentage response, Mini-Mental State Examination (MMSE) score, Barthel Index (BI) index, and expression levels of CD3+, CD4+ and CD8+ in the study group treated with ulinastatin were significantly higher than those in the control group given conventional treatment
Summary
Esophageal cancer is a disease of the digestive system with increasing incidence, mostly among the elderly population. The treatment of esophageal cancer is mainly based on conventional and minimally invasive esophagectomy (MIE) which is a simple operation associated with low trauma and rapid recovery [1-3]. Clinical trials have found that the cognitive function of elderly patients administered MIE are affected to some extent. To investigate the effectiveness of ulinastatin in elderly patients with esophageal cancer, and assess its effects on postoperative complications and cognitive function after thoracic laparoscopic surgery, this study used elderly patients with esophageal cancer after thoracic laparoscopic surgery, as subjects. The response, incidence of complications, cognitive function, inflammatory factors and immune function were compared between subjects who received conventional treatment and those who were given ulinastatin in addition to conventional therapy
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