Abstract
Sesame oil has been used in traditional Taiwanese medicine to relieve the inflammatory pain in people with joint inflammation, toothache, scrapes, and cuts. However, scientific evidence related to the effectiveness or action mechanism of sesame oil on relief of pain and inflammation has not been examined experimentally. Here, we investigated the therapeutic effect of sesame oil on monosodium urate monohydrate (MSU) crystal-induced acute inflammatory response in rats. Air pouch, a pseudosynovial cavity, was established by injecting 24 mL of filtered sterile air subcutaneously in the backs of the rats. At day 0, inflammation in air pouch was induced by injecting MSU crystal (5 mg/rat, suspended in sterilized phosphate buffered saline, pH 7.4), while sesame oil (0, 1, 2, or 4 mL/kg, orally) was given 6 h after MSU crystal injection. Parameters in lavage and skin tissue from the air pouches were assessed 6 h after sesame oil was given. Sesame oil decreased MSU crystal-induced total cell counts, tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 levels in lavage and pouch tissue. Sesame oil significantly decreased leukocyte and neutrophil counts in lavage compared with MSU crystal alone group. Sesame oil decreased activated mast cell counts in skin tissue in MSU crystal-treated rats. Sesame oil significantly decreased nuclear factor (NF)-κB activity and IL-4 level in isolated mast cells from rats treated with MSU crystal. Furthermore, sesame oil decreased lavage complement proteins C3a and C5a levels in MSU crystal-treated rats. In conclusion, sesame oil shows a potent therapeutic effect against MSU crystal-induced acute inflammatory response in rats.
Highlights
Sesame oil is derived from the plant species Sesamum indicum L., an herbaceous annual belonging to the Pedaliaceae family (Kubes & Grabger 1996)
The formation of monosodium urate (MSU) crystals in the joint synovium under hyperuricemia condition is the main cause of acute gouty arthritis (Choi et al 2005a)
Activated neutrophils produce a large number of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β (Guerne et al 1989; Terkeltaub et al 1991; Choi et al 2005c), all of which are involved in the pathogenesis and development of acute inflammation of gouty arthritis (Di Giovine et al 1987)
Summary
Sesame oil is derived from the plant species Sesamum indicum L., an herbaceous annual belonging to the Pedaliaceae family (Kubes & Grabger 1996). An extremely painful arthritis with relapsing inflammatory attacks, is a common inflammatory joint. The formation of monosodium urate (MSU) crystals in the joint synovium under hyperuricemia condition is the main cause of acute gouty arthritis (Choi et al 2005a). Neutrophils activation and infiltration to joint synovium after MSU crystal stimulation is a central feature of acute gouty inflammation (Choi et al 2005b; Popa-Nita & Naccache 2010). Activated neutrophils produce a large number of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β (Guerne et al 1989; Terkeltaub et al 1991; Choi et al 2005c), all of which are involved in the pathogenesis and development of acute inflammation of gouty arthritis (Di Giovine et al 1987)
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